Protein Details: Amiloride-sensitive sodium channel subunit beta
Protein ID
ICDB_Pro_0148
Protein Name
Amiloride-sensitive sodium channel subunit beta
Gene Name
scnn1b; enacbeta
Organism
Neoceratodus forsteri (Australian lungfish) (Ceratodus forsteri)
Length
651 amino acids
AlphaFoldDB
AF-H1AFJ6-F1-model_v4.pdb
Function
Sodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride. Mediates the electrodiffusion of the luminal sodium (and water; which follows osmotically) through the apical membrane of epithelial cells. Plays an essential role in electrolyte and blood pressure homeostasis; but also in airway surface liquid homeostasis; which is important for proper clearance of mucus.
Sequence
MFLKRWFIRALHRLQKGPGYGYSELFVWYCNNTNTHGPKRLIIEGPKKKTLWSLFTVTFACLVFWQWGLLIQTYLSWGVSVSLSVGFRGMDFPAVTVCNVNPFKYSKVKPLLKELDELVDILLEQFYSYSTNGTLPVVFPDMRSSYLTGDPPPWYQIPLVMIDETDADNPTVTNVLGTDALSPTNNSTTNSSTEARRYKVAFHLCNTNGTDCFYKNFSSSLEAVKEWYTLQYIDIISKLPLSQKVEMGYSGKDFILTCLFGGEACNYDNFTQFYHSSYGNCYVFNWGLDGNVLIVSNPGVGFGLQLALDVNQEEYIPFLTTRAGARFLLHTQNTFPFVETMGTYALVGTVTSVGILVDEVQRMGQPYGTCTTDGLDVPIDNLYSQYNLSYTMQSCLWSCFQIQMVNSCGCAYYLYPLPEGATYCNNQNNSDWAYCYYLLQDSKDHKNECLQTCIQTCNELQFRISTSMADWPSESSEDWIFHVLSYERDDSTNITMKRDGVLKLNLYFKEFNYRVITESVATNVVWLLSNLGGQFGFWMGGSVLCIIEFGEVFIDCIWIAVIRFVKWYKNRKERQVQAQYADPPPTVSELVEGYTNQGFQPDIINSCSPQAQPPDLYLPTTLEIPGTPPPKYDSLRVHPIDTEHHSDSEDL
PDB Structures
Ligand Binding
Binding Site
Disease
Location
Strongly expressed in gill; kidney and rectum and more weakly in brain; eye; liver and muscle
DOI ID
10.1098/rspb.2012.1945